Praktikum Farmasetika - Pembuatan Sediaan Pulvis

Introduction

This tutorial provides a comprehensive guide on the preparation of powdered formulations, known as sediaan pulvis, as part of the Farmasetika practical course at FIKES UNSOED. This process is essential for pharmacy students, as it lays the foundation for understanding pharmaceutical formulations and their applications.

Step 1: Gather Necessary Materials

Before starting the preparation of sediaan pulvis, ensure you have all the required materials:

• Active ingredient(s): Identify the drug or compounds to be powdered.
• Excipients: Gather any additional substances needed for the formulation (e.g., fillers, binders).
• Equipment:
  • Mortar and pestle or a grinding machine
  • Sieve
  • Weighing scale
  • Spatula
  • Measuring cylinders
  • Container for the final product

Step 2: Weigh the Ingredients

Accurate measurement is crucial for the success of the formulation. Follow these steps:

1. Use the weighing scale to measure the active ingredient(s) and excipients.
2. Record the weights for reference.
3. Ensure the amounts are in accordance with the formulation requirements.

Step 3: Grind the Ingredients

The next step involves grinding the active ingredients and excipients to achieve a fine powder. Here's how to do it:

1. Place the measured ingredients into the mortar.
2. Use the pestle to grind the ingredients until they reach a uniform particle size.
3. If using a grinding machine, follow the manufacturer’s instructions for operation.

Step 4: Sieve the Powder

Sifting the powder helps to achieve a consistent texture and removes any larger particles. Follow these steps:

1. Place the ground powder into a sieve.
2. Shake the sieve gently to allow finer particles to pass through while retaining larger ones.
3. Collect the fine powder in a clean container.

Step 5: Mix the Ingredients

To ensure an even distribution of the active ingredient within the excipients, mix thoroughly:

1. Use a spatula to transfer the sieved powder back into the mortar.
2. Mix gently but thoroughly to achieve a homogeneous mixture.
3. If necessary, add small amounts of excipients gradually while mixing.

Step 6: Package the Final Product

Once the sediaan pulvis is well-mixed, it’s time to package it:

1. Transfer the powder into appropriate containers (e.g., bottles, sachets).
2. Label the containers with relevant information, including the name of the formulation, active ingredient(s), and date of preparation.
3. Store the product in a cool, dry place to maintain its stability.

Conclusion

In this tutorial, we covered the essential steps for preparing sediaan pulvis, including gathering materials, weighing ingredients, grinding, sieving, mixing, and packaging. Mastering these techniques is vital for pharmacy students as they prepare for more complex formulations in the future. As a next step, consider exploring other dosage forms and their unique preparation processes to expand your pharmaceutical knowledge.