Praktikum Teknologi Sediaan Farmasi Liquid dan Semisolid: Pembuatan Sediaan Suspensi

Introduction

This tutorial provides a step-by-step guide on the preparation of pharmaceutical suspensions, focusing on both liquid and semisolid dosage forms. Understanding how to create suspensions is crucial in pharmaceutical technology as it ensures the effective delivery of active ingredients in a stable form.

Step 1: Gather Necessary Materials

Before starting the preparation of the suspension, ensure you have all required materials and equipment:

• Ingredients:

  • Active pharmaceutical ingredient (API)
  • Appropriate suspending agents
  • Vehicle (solvent) for the suspension
  • Preservatives (if applicable)

• Equipment:

  • Mortar and pestle or a suitable grinder
  • Beakers or mixing containers
  • Stirring rod or magnetic stirrer
  • Measuring cylinder
  • pH meter or pH strips (if pH adjustment is necessary)

Step 2: Prepare the Active Ingredient

• Weigh the API: Use an accurate scale to measure the required amount of the active ingredient.
• Pulverize the API: If the API is in solid form, use a mortar and pestle to grind it into a fine powder. This improves dispersion and stability in the suspension.

Step 3: Select and Prepare the Suspending Agent

• Choose a suitable suspending agent: Common agents include xanthan gum, methylcellulose, or carboxymethylcellulose.
• Dissolve the suspending agent: Mix the suspending agent with a portion of the vehicle to ensure it is fully hydrated and forms a gel-like consistency.

Step 4: Combine the Ingredients

• Mix the API with the suspending agent: Gradually add the pulverized API into the prepared suspending agent mixture. Use a stirring rod or magnetic stirrer to create a uniform blend.
• Add the remaining vehicle: Slowly incorporate the rest of the vehicle into the mixture, ensuring thorough mixing to achieve a homogenous suspension.

Step 5: Adjust pH and Stability

• Check the pH: Use a pH meter or strips to ensure the suspension's pH is within the desired range, as this can affect the stability and efficacy.
• Make adjustments if necessary: If the pH is not optimal, use pH adjusters (like citric acid or sodium hydroxide) to bring it to the correct level.

Step 6: Packaging and Labeling

• Transfer the suspension into suitable containers: Use sterile bottles or vials, ensuring they are clean and dry.
• Label the containers: Include essential information such as the name of the suspension, date of preparation, and any storage instructions.

Conclusion

You have now completed the preparation of a pharmaceutical suspension. Key takeaways include the importance of proper ingredient selection, thorough mixing, and pH adjustment for stability. Next steps may involve conducting stability tests or preparing for clinical evaluations if this suspension is intended for further use. Always ensure to follow good manufacturing practices for the highest quality results.