Praktikum Farmasetika - Pembuatan Resep Krim 4

Introduction

This tutorial provides a step-by-step guide on creating a cream formulation, specifically focusing on the process demonstrated in the video "Praktikum Farmasetika - Pembuatan Resep Krim 4." Understanding the preparation of medicinal creams is crucial for pharmacy students, as it equips them with practical skills for compounding pharmaceutical formulations.

Step 1: Gather Required Materials

Before starting the formulation process, ensure you have all the necessary materials:

• Ingredients:

  • Active pharmaceutical ingredients (API)
  • Emulsifiers
  • Preservatives
  • Stabilizers
  • Water phase components

• Equipment:

  • Glass beakers
  • Spatula
  • Heating mantle or hot plate
  • pH meter
  • Homogenizer (if available)
  • Weighing scale

Practical Tips

• Double-check the quantities of each ingredient against your recipe to avoid mistakes.
• Ensure all equipment is clean and sterilized to prevent contamination.

Step 2: Measure Ingredients

Precise measurements are critical for the success of the formulation.

• Use a digital scale to weigh each ingredient accurately.
• Record the weights for each component to ensure consistency in future batches.

Common Pitfalls

• Avoid using approximate measurements; accuracy is key.
• Make sure to tare the scale before measuring each ingredient.

Step 3: Prepare the Oil Phase

The first phase of the cream preparation involves mixing the oil-soluble ingredients.

• Combine emulsifiers and oils in a glass beaker.
• Heat the mixture gently using a heating mantle until all solids are dissolved.

Important Note

• Monitor the temperature to prevent overheating, which can degrade the ingredients.

Step 4: Prepare the Water Phase

In a separate beaker, prepare the water-soluble ingredients.

• Measure and combine water and any water-soluble components.
• Heat to a similar temperature as the oil phase to facilitate emulsification.

Step 5: Emulsification

Combine the oil and water phases to form an emulsion.

• Slowly add the water phase to the oil phase while stirring continuously.
• Use a homogenizer if available for a finer emulsion texture.

Practical Advice

• Stir vigorously to ensure a uniform mixture.
• Adjust the pH using citric acid or sodium hydroxide if necessary, aiming for a pH that suits skin compatibility.

Step 6: Add Active Ingredients and Preservatives

Once the emulsion is stable, incorporate the active ingredients and preservatives.

• Gently fold in the active ingredients to maintain their efficacy.
• Add preservatives to ensure the product's shelf life and stability.

Step 7: Final Product Adjustments

Check the final product for consistency and appearance.

• If the cream is too thick, add small amounts of water until the desired consistency is achieved.
• If it is too thin, consider adding more emulsifying agent.

Conclusion

In this tutorial, we detailed the process of preparing a cream formulation, from gathering materials to emulsification and final adjustments. Remember to maintain accuracy in measurements and monitor temperatures throughout the process. Practicing these steps will enhance your skills in pharmaceutical formulations, preparing you for real-world applications in pharmacy. For further learning, consider exploring additional formulations or experimenting with different active ingredients.