HER2 in Cancer

Introduction

This tutorial explains the role of HER2 in cancer and its significance in treatment decisions. Understanding HER2 can empower patients to engage in informed discussions with their healthcare providers about their cancer care options.

Step 1: Understand HER2 and Its Role in Cancer

• HER2 is a protein that can promote the growth of cancer cells.
• In certain cancers, particularly breast and gastric cancers, HER2 can be overexpressed, leading to aggressive tumor growth.
• Determining HER2 status is crucial as it influences treatment decisions and potential outcomes.

Step 2: Ask About HER2 Testing

• If diagnosed with cancer, inquire your doctor about testing for HER2 status.
• Testing methods include:
  • Immunohistochemistry (IHC): Measures protein expression.
  • Fluorescence in situ hybridization (FISH): Detects HER2 gene amplification.
• Understanding your HER2 status can guide tailored treatment options.

Step 3: Learn About Treatment Options Based on HER2 Status

• HER2-positive cancers may benefit from targeted therapies, such as:
  • Trastuzumab (Herceptin): A monoclonal antibody that specifically targets HER2.
  • Pertuzumab (Perjeta): Often used in combination with trastuzumab for enhanced effectiveness.
• Discuss with your doctor the most appropriate treatment regimen based on your HER2 status.

Step 4: Explore Additional Biomarkers

• HER2 is one of several biomarkers; others can also play significant roles in cancer treatment.
• Ask about testing for other biomarkers that may influence therapy, such as hormone receptors (ER/PR) and PD-L1 status.
• Awareness of all relevant biomarkers can lead to a more personalized approach to cancer care.

Conclusion

Understanding HER2 and its implications in cancer treatment is vital for patients. Be proactive in discussing HER2 testing with your healthcare provider and explore potential targeted therapies. Staying informed about your cancer's biology can significantly influence your treatment choices and outcomes. For more information on HER2 and other biomarkers, visit CancerCare's biomarker resource.