Praktikum Teknologi Sediaan Farmasi Liquid dan Semisolid: Pembuatan Sediaan Krim Hidrokortison

Introduction

This tutorial provides a step-by-step guide for creating hydrocortisone cream, a common pharmaceutical preparation in liquid and semisolid forms. Understanding this process is essential for students and professionals in pharmacy technology, as it combines practical skills with theoretical knowledge in pharmaceutical science.

Step 1: Gather Materials

Before starting the preparation, ensure you have all necessary materials and equipment:

• Ingredients:

  • Hydrocortisone powder
  • Emollients (e.g., cetyl alcohol, stearyl alcohol)
  • Water
  • Preservatives (if required)

• Equipment:

  • Balance for weighing ingredients
  • Beakers and mixing bowls
  • Heating source (hot plate or water bath)
  • Thermometer
  • Homogenizer or mixer
  • Containers for the final product

Step 2: Weigh Ingredients Accurately

Accurate measurements are crucial for the effectiveness and safety of the cream.

• Use a balance to weigh:
  • The prescribed amount of hydrocortisone powder
  • Emollients and other excipients based on your formulation

Step 3: Prepare the Oil Phase

The oil phase involves melting the emollients to create a uniform base.

• Heat the emollients in a beaker over a water bath until fully melted.
• Monitor the temperature to avoid overheating, typically around 60-70°C.

Step 4: Prepare the Water Phase

Simultaneously, prepare the water phase.

• Heat the required amount of water in a separate beaker to the same temperature as the oil phase.
• If using preservatives, dissolve them in the heated water.

Step 5: Combine Oil and Water Phases

Once both phases are at the same temperature, combine them to form an emulsion.

• Slowly add the water phase to the oil phase while continuously mixing.
• Use a homogenizer or mixer to ensure a uniform consistency.

Step 6: Incorporate Hydrocortisone

After achieving a stable emulsion, it's time to add the active ingredient.

• Gradually sprinkle the hydrocortisone powder into the mixture while stirring.
• Ensure complete dispersion for uniform potency throughout the cream.

Step 7: Cool and Adjust pH

Allow the mixture to cool while monitoring its consistency and pH.

• Stir occasionally to maintain uniformity.
• Check the pH; it should typically be between 4.5 and 6.5. Adjust if necessary.

Step 8: Package the Cream

Once cooled and properly mixed, package the cream for storage.

• Transfer the cream into clean, sterilized containers.
• Label the containers with the name, concentration, and date of preparation.

Conclusion

Creating hydrocortisone cream involves careful measurement, heating, and mixing to ensure a stable and effective product. By following these steps, you can gain practical experience in pharmaceutical preparations. For further learning, consider exploring additional formulations or variations in semisolid dosage forms.