Mastermind Genomic Intelligence Platform: Curated Evidence and Article Viewer

Introduction

This tutorial will guide you through using the Mastermind Genomic Intelligence Platform, focusing on its curated evidence and article viewer features. Mastermind is designed to help you interpret genetic variants by providing comprehensive literature and evidence for your research needs. Whether you are a researcher, clinician, or simply interested in genomics, this guide will help you navigate the platform effectively.

Step 1: Create Your Mastermind Account

To access Mastermind’s features, you need to create an account. Follow these steps:

1. Visit the Mastermind sign-up page: Mastermind Sign-Up.
2. Fill in the required information:
   • Name
   • Email address
   • Password
3. Click on the sign-up button to create your account.
4. No payment information is required at this stage.

Step 2: Explore the Curated Evidence Feature

Once you have logged in, you can start exploring the curated evidence for variants:

1. Navigate to the search bar on the main dashboard.
2. Enter the genetic variant you are interested in (e.g., BRCA1, EGFR).
3. Click on the search icon.
4. Review the curated evidence provided, which will include:
   • Variant classification
   • Associated conditions
   • Supporting literature
5. Click on any evidence entry for more detailed information.

Step 3: Utilize the Article Viewer

To dive deeper into the literature related to your variant, use the article viewer:

1. From the curated evidence page, find the literature section.
2. Browse through the list of articles linked to your variant.
3. Click on an article title to open it in the viewer.
4. Use the following features in the article viewer:
   • Search within the article: Enter keywords to find specific information.
   • Highlighting and Notes: Use these tools to mark important sections for later reference.
5. Download or export articles as needed for your research.

Step 4: Analyze Evidence and Literature

To effectively interpret your findings, analyze the evidence and literature:

1. Compare multiple sources of evidence to see how they align or differ.
2. Pay attention to the date of publication and the credibility of the sources.
3. Take notes on key findings that are relevant to your variant interpretation.
4. If applicable, discuss your findings with colleagues or in relevant forums for additional insights.

Conclusion

The Mastermind Genomic Intelligence Platform is a powerful tool for accessing curated evidence and literature on genetic variants. By following the steps outlined in this guide, you can create an account, explore curated evidence, utilize the article viewer, and analyze findings effectively. As you become more familiar with the platform, you will enhance your ability to interpret genes and variants accurately. Consider exploring additional features and functionalities within Mastermind to further enrich your research.